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22 specialties · 759 conditions

Conditions

Every condition. Open any to start a guided workup in the station — 189 are phenotype-stratified into mechanism-targeted treatment.

759 conditions189 phenotype-stratified22 specialties

Setting
759 of 759 conditions

Allergy & Immunology

5 conditions

Cardiovascular

252 conditions
Acute aortic aneurysm + malperfusion in hypertensive emergency (anti-impulse + emergent endovascular/open repair)Acute decompensated heart failureAcute decompensated HF complicated by atrial fibrillation with rapid ventricular responseAcute heart failure — de novo (first presentation)Acute HF — acute decompensation on chronic HFAcute HF — alcoholic cardiomyopathyAcute HF — Chemotherapy / cancer therapy-induced cardiomyopathy (CTRCD)Acute HF — constrictive pericarditis decompensationAcute HF — diabetic cardiomyopathyAcute HF — eosinophilic myocarditis decompensation (non-shock)Acute HF — frail elderly (age ≥80, CFS ≥6)Acute HF — HD-dependent ESRDAcute HF — hemochromatosis / iron-overload cardiomyopathyAcute HF — high-output from severe anemia (Hb <7)Acute HF — Iatrogenic hypothyroid (post-thyroidectomy / post-RAI / over-treated thionamide)Acute HF — Immune checkpoint inhibitor (ICI) cardiotoxicity / fulminant myocarditisAcute HF — Infusion-reaction cardiotoxicity (mAb / CAR-T CRS / transfusion reaction / contrast)Acute HF — Peripartum cardiomyopathy (PPCM)Acute HF — RV-predominant decompensated HFAcute HF — sepsis-induced cardiomyopathy (SICM)Acute HF — Takotsubo (apical ballooning) decompensation (non-shock)Acute HF — thyrotoxicosis-induced (high-output)Acute HF — Type-1 cardiorenal syndrome (ADHF + AKI)Acute HF — viral cardiomyopathy / myocarditis decompensation (non-shock)Acute renovascular flash pulmonary edema (Pickering syndrome)ADHF complicated by cardiogenic shock (composite)ADHF in cardiac amyloidosis (ATTR-CM and AL)ADHF in cardiac transplant recipient (CAV / ACR / AMR)ADHF in Fabry cardiomyopathyADHF in SLE myocarditisAdult aortic coarctation (native + repaired, chronic ACHD)Adult atrial septal defect (chronic ACHD)Adult Fontan circulation (single-ventricle palliation, chronic ACHD)Adult ventricular septal defect (chronic ACHD)AL (light-chain) cardiac amyloidosis — chronic (cardiology arm)Alcohol-related atrial flutter ("Holiday Heart Syndrome")Amphetamine / stimulant WITHDRAWAL hypertensive crisis (rebound HTN + autonomic instability + tachy + diaphoresis + tremor + agitation/depression overlap 6-72 h after abrupt cessation of chronic stimulant therapy or use)Anterior wall STEMI (LAD culprit)Antiphospholipid syndrome (APS) DVT — warfarin preferred, DOAC avoidedAortic dissection (Stanford A / B + IMH / PAU)Aortic dissection in hypertensive crisis (HR + dP/dt FIRST, then SBP)Aortic stenosis (calcific + bicuspid + rheumatic; high-gradient & low-flow/low-gradient)Arrhythmogenic RV / biventricular cardiomyopathy (ARVC/ALVC, chronic)Atrial fibrillation (rate / rhythm / anticoagulation)Atrial flutter (typical and atypical)Atrial flutter / atrial tachycardia — post-cardiac-surgery (POAF)Atrial flutter / IART in adult congenital heart disease (ACHD)Atrial flutter complicated by acute embolic strokeAtrial flutter in adult unrepaired/late-repaired atrial septal defect (RA volume overload → CTI macroreentry)Atrial flutter in cardiac amyloidosis (ATTR-CM and AL)Atrial flutter in the long-term endurance athleteAtrial flutter precipitating cardiogenic shock (AFL with RVR + low-output state)Atrial flutter with concurrent acute pulmonary embolismAtypical / scar-mediated / left atrial flutterAutonomic dysreflexia (SCI ≥T6; remove trigger FIRST, short-acting titratable drugs second)Brady-tachy syndrome / sick sinus syndromeBrugada syndrome (chronic ambulatory — SCD risk stratification)Cancer-associated DVT (CAT)Cardiac sarcoidosis (chronic — immunosuppression + arrhythmic protection)Cardiac tamponadeCardiac tamponade — blunt chest trauma (MVA, fall, sternal blow)Cardiac tamponade — chylopericardium (chylous pericardial effusion)Cardiac tamponade — Dressler syndrome (post-cardiac-injury syndrome)Cardiac tamponade — effusive-constrictive pericarditis (Sagristà-Sauleda syndrome)Cardiac tamponade — HIV-related pericardial effusionCardiac tamponade — late post-radiation effusive-constrictive pericarditisCardiac tamponade — malignant pericardial effusionCardiac tamponade — myxedema-related pericardial effusionCardiac tamponade — post-procedural / hemopericardium / iatrogenicCardiac tamponade — post-RF ablation iatrogenic (PVI / atypical-flutter / steam-pop)Cardiac tamponade — post-TAVR (transcatheter aortic valve replacement)Cardiac tamponade — purulent bacterial pericarditisCardiac tamponade — radiation-induced pericardial diseaseCardiac tamponade — tuberculous pericarditisCardiac tamponade — Type A aortic dissection-related (hemopericardium)Cardiac tamponade — uremic pericardial effusionCardio-obstetric: pre-pregnancy risk + pregnancy cardiac management (cross-system)Cardio-oncology cardiotoxicity surveillance & management (chronic, cross-system)Cardiogenic shock — acromegaly-induced cardiomyopathyCardiogenic shock — acute severe aortic regurgitationCardiogenic shock — acute severe mitral regurgitationCardiogenic shock — acute severe MR from infective endocarditisCardiogenic shock — after non-cardiac surgery (perioperative)Cardiogenic shock — amniotic fluid embolism (AFE)Cardiogenic shock — anthracycline-induced cardiomyopathy with shock physiologyCardiogenic shock — bacterial myocarditis (Staph, Strep, diphtheria, TB, meningococcal)Cardiogenic shock — Beta-blocker overdose (HIE-first toxicologic CS)Cardiogenic shock — Brugada syndrome electrical stormCardiogenic shock — Calcium channel blocker overdose (HIE-first toxicologic CS)Cardiogenic shock — cardiac amyloidosis (ATTR-CM and AL)Cardiogenic shock — COVID-19-associated myocarditis (infection or post-mRNA-vaccine)Cardiogenic shock — Eosinophilic myocarditis (hypersensitivity / parasitic / HES / EGPA)Cardiogenic shock — fulminant viral / immune myocarditisCardiogenic shock — giant cell myocarditis (GCM)Cardiogenic shock — Long-QT torsades de pointes (TdP) electrical stormCardiogenic shock — PE-related (massive PE with RV failure)Cardiogenic shock — peripartum cardiomyopathy (PPCM, severe)Cardiogenic shock — Post non-CABG cardiac surgery (valve / transplant / complex)Cardiogenic shock — Post pacemaker / ICD / CRT implantationCardiogenic shock — Post-CABGCardiogenic shock — post-hematopoietic-stem-cell-transplant recipientCardiogenic shock — RV-predominantCardiogenic shock — SCAI Stage D (deteriorating)Cardiogenic shock — SCAI Stage E (extremis / refractory)Cardiogenic shock — septic-mixed (SICM + distributive overlap)Cardiogenic shock — Takotsubo (stress) cardiomyopathyCardiogenic shock — Takotsubo with dynamic LVOT obstruction (SAM-mediated)Cardiogenic shock (SCAI A–E)Cardiogenic shock / high-grade AV block — Lyme carditisCatecholaminergic polymorphic VT (CPVT, chronic)Chronic aortic regurgitationChronic cardiorenal syndrome (CRS type 2/4, cross-system)Chronic coronary / ASCVD secondary preventionChronic primary (degenerative) mitral regurgitationChronic secondary (functional) mitral regurgitationChronic tricuspid regurgitationClonidine / α2-agonist withdrawal hypertensive crisis (rebound NE surge HTN + tachy + diaphoresis + tremor 18-72 h after abrupt cessation of clonidine, methyldopa, dexmedetomidine, or guanfacine)Cocaine / sympathomimetic hypertensive crisis (alpha-driven HTN + tachycardia + coronary vasospasm)Cocaine-induced atrial flutter (sympathetic + α-adrenergic + Na-channel substrate)Cocaine-induced NSTEMI (sympathetic crisis + vasospasm)Cocaine-induced STEMI (sympathetic crisis + vasospasm + thrombosis)Congenital Long QT Syndrome (chronic — genotype-driven)Cushing syndrome HTN crisis (cortisol-excess–driven severe HTN with hypokalemic alkalosis)Deep vein thrombosisDistal DVT (isolated calf vein)DVT during pregnancy / postpartumDVT from prolonged immobilization (post-stroke / SCI / post-arthroplasty / prolonged ICU)DVT in JAK2-V617F-positive myeloproliferative neoplasm (PV / ET / PMF)DVT in paroxysmal nocturnal hemoglobinuria (PNH)DVT with coexistent pulmonary embolism (combined VTE)DVT/VTE in Behçet's disease (variable-vessel vasculitis)DVT/VTE in thromboangiitis obliterans (Buerger's disease)DVT/VTE with Heparin-Induced Thrombocytopenia (HIT/HITT)Dyslipidemia / lipid managementEbstein anomaly of the tricuspid valve (adult, chronic ACHD)Eisenmenger syndrome (chronic ACHD — PAH-CHD severe end)Factor V Leiden thrombophilia DVT (heterozygous or homozygous)Genetic / familial dilated cardiomyopathy (LMNA/FLNC/TTN/RBM20/DSP, chronic)Glucocorticoid-induced hypertensive crisis (severe HTN driven by high-dose prednisone >20 mg/d, methylprednisolone, or hydrocortisone via mineralocorticoid receptor activation, Na+ retention, RAAS upregulation, and vascular sensitization — fluorinated dexamethasone less implicated)Heart failure (chronic, GDMT titration)Heart failure in the frail older adult (chronic, sub-population)Heart failure with improved EF (HFimpEF — recovered, prior LVEF ≤40)Heart failure with mildly reduced EF (HFmrEF, LVEF 41–49)Heart failure with preserved EF (HFpEF, LVEF ≥50)Heart failure with reduced EF (HFrEF, LVEF ≤40)HELLP syndrome with severe HTN + eclampsia overlap (peripartum HTN crisis)High-risk NSTE-ACS (cath ≤24 h)Hypertension (chronic management)Hypertensive emergencyHypertensive emergency in acute ischemic stroke (autoregulation-aware BP target by reperfusion eligibility)Hypertensive emergency in kidney transplant recipient (CNI / rejection / TRAS / native disease recurrence)Hypertensive emergency with acute (flash) pulmonary edemaHypertensive encephalopathy (HTN crisis with cerebral edema / AMS / papilledema)Hypertrophic cardiomyopathy (chronic management)Hypertrophic cardiomyopathy with acute decompensationIatrogenic post-PVI atypical LA flutter (gap-related macroreentry)Idiopathic pulmonary arterial hypertension (Group 1 PAH)Incidental DVT on cancer-staging imagingInfective endocarditis (Duke-ISCVID)Inferior wall STEMI (RCA / LCx culprit)Intermediate-risk NSTE-ACS (cath 25-72 h)Isolated posterior wall STEMI (LCx / PDA culprit)Late-presenter STEMI (>12 h after symptom onset)Left main coronary artery (LMCA) STEMI-equivalentLow-flow low-gradient severe aortic stenosis (classical + paradoxical)LV non-compaction / hypertrabeculation cardiomyopathy (chronic)MAOI–tyramine hypertensive crisis ("cheese effect" — severe occipital headache + HTN crisis + tachycardia + diaphoresis after MAOI + tyramine-rich food or sympathomimetic exposure)May-Thurner syndrome (left iliac vein compression DVT)Methamphetamine / amphetamine-derivative hypertensive crisis (sustained ~12-24 h α-adrenergic + dopaminergic + serotonergic crisis with hyperthermia + agitation + meth-induced cardiomyopathy risk)MINOCA — MI with Non-Obstructive Coronary ArteriesMitral stenosis (rheumatic + degenerative)Mixed aortic valve disease (combined AS + AR)Nephrotic-syndrome DVT (urinary AT-III/protein S loss; LMWH preferred over DOAC)Neurally-Mediated Reflex Syncope (vasovagal / situational / carotid sinus)NSAID-induced hypertensive crisis (severe HTN driven by COX-1/COX-2 inhibition from indomethacin, ketorolac, naproxen, ibuprofen, diclofenac, or celecoxib — most severe in CKD, HF, elderly, cirrhosis, or with concurrent ACEi/ARB/diuretic via "triple whammy" mechanism causing AKI; aspirin LESS implicated at low cardiovascular dose 81 mg/d)NSTEMI — diabetic silent / atypical (autonomic neuropathy; anginal-equivalent presentation)NSTEMI / NSTE-ACS (UA + NSTEMI)NSTEMI from spontaneous coronary artery dissection (SCAD)NSTEMI in active-cancer patient (cardio-oncology bleeding-risk balance)NSTEMI in dialysis/ESKD — troponin delta (not absolute) drives diagnosis; renally-reconciled therapyNSTEMI in heart-transplant recipient — cardiac allograft vasculopathy (CAV)-drivenNSTEMI in hypertrophic cardiomyopathy — microvascular ischemia + supply-demand mismatchNSTEMI peri-operative — within 30 days post-CABG (UDMI Type 5 NSTEMI variant)Obesity + obstructive sleep apnea (OSA) hypertensive emergency (resistant-HTN phenotype with sympathetic + RAAS overdrive; CPAP + weight loss + MRA central to long-term control)Octogenarian NSTE-ACS — conservative strategyPE-related cardiac arrest — peri-arrest thrombolysis + prolonged CPR; embolectomy/ECPR if lysis failsPediatric cardiomyopathy (chronic, sub-population)Pericarditis (acute / recurrent / IMPS)Pheochromocytoma / paraganglioma crisis (catecholamine-driven episodic HTN crisis)Post-cardiac-arrest care — arrhythmogenic right-ventricular cardiomyopathy (ARVC; PKP2 / DSP desmosomal; exercise-induced VT/VF arrest)Post-cardiac-arrest care — Brugada syndrome channelopathy (SCN5A type 1 ECG; sleep / fever-triggered VF)Post-cardiac-arrest care — cocaine-related arrest (sympathomimetic + Na-channel blockade)Post-cardiac-arrest care — commotio cordis (R-on-T blunt chest impact)Post-cardiac-arrest care — congenital long-QT channelopathy (KCNQ1 / KCNH2 / SCN5A) with TdP-arrestPost-cardiac-arrest care — CPVT channelopathy (RYR2 / CASQ2; exercise- or emotion-triggered bidirectional VT → VF arrest)Post-cardiac-arrest care — drowning-induced cardiac arrestPost-cardiac-arrest care — electrical-injury-induced arrestPost-cardiac-arrest care — hypothermic cardiac arrestPost-cardiac-arrest care — initial non-shockable rhythm (PEA/asystole)Post-cardiac-arrest care — initial shockable rhythm (VF/pVT)Post-cardiac-arrest care — opioid-overdose-induced arrestPost-cardiac-arrest care — peripartum maternal arrestPost-cardiac-arrest care — tricyclic antidepressant (TCA) overdosePost-cardiac-arrest care — TTM protocol (cooling, rewarm, fever prevention)Post-cardiac-arrest care (cardiology-driven, ischemic-OHCA pathway)Post-orthopedic-arthroplasty DVT (post-THA/TKA/hip-fracture; ASA vs DOAC vs LMWH per AAOS 2025 + ACCP)Post-PCI stent thrombosis (NSTEMI presentation)Pre-excited atrial flutter (WPW) — DCCV / procainamide; AV-nodal blockers ABSOLUTELY contraindicatedPreoperative Cardiac Risk Evaluation (Noncardiac Surgery)Primary aldosteronism (Conn / BAH) HTN crisis (autonomous aldosterone–driven severe HTN with hypokalemic alkalosis)Prinzmetal / vasospastic angina presenting as NSTE-ACSProsthetic heart valve — chronic managementProximal DVT (iliofemoral / popliteal)Pulmonary hypertension crisis in scleroderma (PAH-SSc WHO Group 1 — RV failure with shock)Pulmonary hypertension due to left heart disease (Group 2 PH, cross-system)Radiation-induced STEMI (post chest/mediastinal XRT)Recurrent DVT on therapeutic anticoagulation (treatment failure)Recurrent STEMI in patient with prior MI historyRefractory atrial flutter — cardioversion-failedRepaired Tetralogy of Fallot (adult, chronic ACHD)Resistant hypertension (≥3 meds at max + diuretic)Restrictive cardiomyopathy (chronic — etiology hunt + RCM-vs-CP pivot)Right-ventricular extension STEMI (proximal RCA)Scleroderma renal crisis (SRC) — renin-driven HTN + AKI + MAHA in systemic sclerosisSerotonin syndrome hypertensive crisis (autonomic instability + neuromuscular hyperactivity + altered mental status + HTN crisis ± hyperthermia)Severe pre-eclampsia / eclampsia (peripartum hypertensive crisis)Spinal-cord-injury DVT/VTE (highest-risk; LMWH within 24-72 h, IPC adjunct, no routine IVC filter)STEMI — antiphospholipid syndrome related (arterial APS thrombosis)STEMI — Behçet-disease-associated coronary vasculitis (variable-vessel vasculitis with aneurysms + thrombosis)STEMI — SLE-associated coronary vasculitis (immune-complex inflammation + premature CAD)STEMI / OMI (acute coronary syndrome)STEMI complicated by mechanical complication (PMR / VSR / free-wall rupture)STEMI complicated by out-of-hospital cardiac arrest with ROSCSTEMI complicated by ventricular electrical storm (≥3 sustained VT/VF/24 h)STEMI from prior Kawasaki disease coronary aneurysm / stenosisSTEMI from spontaneous coronary artery dissection (SCAD)STEMI in cardiac transplant recipient (CAV-driven)STEMI in pregnancy — non-SCAD etiology (atherosclerotic / embolic / thrombotic)STEMI in prior-CABG patient (graft failure or native progression)STEMI in sickle cell disease (vaso-occlusive / microvascular)STEMI post-PCI no-reflow phenomenon (TIMI ≤2 despite patent epicardial vessel)Thyroid storm with HTN-emergency overlap (BWPS ≥45 + AFib-RVR + HF + AMS)Thyrotoxicosis-precipitated atrial flutterTransient ischemic attack (TIA)Transthyretin amyloid cardiomyopathy (ATTR-CM, ATTRv + ATTRwt)Travel-associated DVT (long-haul flight or train >4 h)Type-2 MI (demand ischemia, no plaque rupture)Typical (CTI-dependent) atrial flutterUpper-extremity DVT (subclavian / axillary / brachial)Valvular heart disease (AS / AR / MR / MS)Warfarin-induced skin necrosis (protein C/S deficiency unmasking)Wolff-Parkinson-White / ventricular preexcitation (chronic ablation pathway)

Critical Care

7 conditions

Dermatology

32 conditions
Acne vulgaris (dermatology lens)Actinic keratosis & keratinocyte carcinoma (BCC + cSCC, dermatology lens)Alopecia areata (dermatology lens)Atopic dermatitis (eczema)Basal cell carcinomaBullous pemphigoidCellulitis & erysipelas (dermatology lens)Contact dermatitis — allergic vs irritant (dermatology lens)Cutaneous abscess / furuncle / carbuncle (I&D-primary purulent SSTI)Cutaneous drug eruption — morbilliform vs SCAR (dermatology lens)Cutaneous lupus erythematosus (ACLE / SCLE / discoid + variants)Cutaneous melanoma (dermatology lens)Cutaneous squamous cell carcinomaCutaneous T-cell lymphoma — mycosis fungoides & Sézary syndrome (dermatology lens)Dermatophytosis / tinea (corporis, cruris, pedis, capitis, onychomycosis)Herpes zoster (shingles) — acute reactivation, complications & PHNHidradenitis suppurativa (acne inversa)Lichen planus (dermatology lens)Lichen sclerosus (dermatology lens; BAD 2018 / EDF-EADV S3 2015)Onychomycosis / tinea unguium (fungal nail infection) — AAD 2019; BAD 2014Pemphigus (vulgaris & foliaceus)Pityriasis roseaPlaque psoriasis (dermatology lens)Primary focal hyperhidrosis (International Hyperhidrosis Society / Multispecialty Working Group 2004; Nawrocki & Cha JAAD 2019)Prurigo nodularis (chronic nodular prurigo)Pyoderma gangrenosum (neutrophilic ulcerative dermatosis)Rosacea (dermatology lens)Scabies — classic & crusted (Norwegian)Seborrheic dermatitis (incl. dandruff + infantile cradle cap)Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN)Urticaria (acute & chronic spontaneous/inducible)Vitiligo (autoimmune depigmentation, dermatology lens)

Endocrinology

29 conditions

Gastroenterology

24 conditions

General Medicine

54 conditions
Acute (sudden) vision loss — neuro-ophthalmology / EM triageAcute angle-closure glaucoma (AACG)Acute conjunctivitis (viral / bacterial / allergic, with red-flag red-eye routing)Acute epiglottitis / supraglottitis (airway-emergency triage, controlled airway, IV cephalosporin)Acute ocular trauma (open-globe / orbital emergency triage)Acute otitis externa (incl. necrotizing/malignant OE)Acute otitis media (ENT/EM lens)Acute pharyngitis & tonsillitis (Centor/McIsaac, GAS vs viral, airway-emergency triage)Acute red eye (undifferentiated triage)Acute rhinosinusitis (viral vs ABRS; complications)Adult immunization (preventive)Age-related macular degeneration (dry, GA, and wet/neovascular)Alzheimer disease dementiaBenign paroxysmal positional vertigo (with acute-vertigo triage)Blepharitis, hordeolum (stye), and chalazionCerumen (earwax) impactionCervical cancer screening (adult)Chronic bothersome tinnitus (AAO-HNSF 2014 CPG — CBT first-line; AGAINST routine pharmacotherapy)Chronic rhinosinusitis (CRSsNP vs CRSwNP, biologic-era ladder, EPOS 2020 / AAO-HNS 2015)Colorectal cancer screening (adult)Corneal abrasion & ocular-surface foreign bodyDeep neck space infection (retropharyngeal / parapharyngeal / Ludwig — airway + sepsis triage, CT space-mapping, IV broad-spectrum ± surgical source control)Delirium (older adult)Dementia with Lewy bodiesDeprescribing in older adultsDiabetic retinopathy and diabetic macular edemaDry eye disease (aqueous-deficient and evaporative subtypes)Endophthalmitis (intraocular infection)Epistaxis (anterior & posterior)Falls in older adultsFrailty assessment and polypharmacy managementGeriatric infection syndromes overlay — atypical presentation, blunted fever, UTI stewardship in older adultsHospital-acquired infection (HAI) overlay — CLABSI / CAUTI / VAP-HAP / CDI / SSIInfectious keratitis (corneal ulcer)Lung cancer screening (LDCT, adult)Ménière's disease (recurrent audiovestibular hydrops)Optic neuritis — typical (demyelinating) vs atypical (NMOSD/MOGAD) neuro-ophthalmology lensOrbital cellulitis (vs preseptal)Peritonsillar abscess (quinsy)Postoperative Nausea and VomitingPreseptal (periorbital) cellulitisPressure injury (staging and management)Preventive breast-cancer screening (adult)Preventive cancer screening (adult)Primary open-angle glaucoma (POAG)Recurrent tonsillitis & tonsillectomy candidacy (Paradise criteria, AAO-HNSF 2019 update)Retinal detachment & acute PVD / retinal tear (vitreoretinal lens)Sepsis acquisition bridge — community (CAS) vs healthcare-associated (HCA/HAP)Subconjunctival haemorrhageSudden sensorineural hearing loss (SSNHL — otologic emergency)Temporomandibular disorders (DC/TMD axis-I/II — conservative-first; AGAINST irreversible occlusal therapy)Uveitis (anterior / intermediate / posterior / panuveitis)Vascular dementiaVestibular neuritis / acute labyrinthitis (acute vestibular syndrome, peripheral)

Hematology

16 conditions

Hepatology

6 conditions

Infectious Disease

34 conditions
Acute Osteomyelitis & Septic ArthritisAcute pyelonephritis (uncomplicated → complicated)Bacterial meningitis (acute, community-acquired)Candidemia / invasive candidiasisCatheter-related bloodstream infection (CRBSI / CLABSI)Cellulitis & erysipelasCerebral toxoplasmosis (HIV-associated and immunocompromised) — DHHS 2024 OI + Dannemann ACTG (Ann Intern Med 1992 PMID 1727093) + Katlama European RCT (CID 1996 PMID 8838183)CMV disease + reactivation in immunocompromised hosts (HSCT / SOT / advanced HIV / biologic) — AST IDCOP 2019; ASBMT/IDSA HSCT; DHHS 2024 OI; Marty NEJM 2017 PMID 29211658CMV end-organ disease (pneumonia / colitis / retinitis / hepatitis / encephalitis) — Kotton Transplantation 2018 PMID 29596116 + Ljungman CID 2024 PMID 39041385 + Avery SOLSTICE CID 2022 PMID 34864943COVID-19 inpatient managementCryptococcal meningitis (HIV-associated and non-HIV)Dengue (DENV-1/2/3/4) — without warning signs + with warning signs (critical phase) + severe dengue (DSS / bleeding / organ failure) + pregnancy + secondary heterologous infection + returning traveler differential + fluid overload recovery + vaccine decision (Dengvaxia seropositive-only / Qdenga any serostatus where approved)Drug-resistant tuberculosis (MDR / pre-XDR / XDR)Endemic mycoses (Histoplasmosis / Coccidioidomycosis / Blastomycosis / Paracoccidioidomycosis)Hepatitis C — initial evaluation & DAAHIV — initial evaluation & rapid ART startInfective endocarditis (native / prosthetic / CIED / right-sided)Influenza (acute)Invasive aspergillosisLyme disease (early localized → late)Malaria (uncomplicated + severe)Measles (rubeola) — primary measles + pneumonia + ADEM + SSPE + atypical immunocompromised + immune amnesia + post-exposure prophylaxis + MMR vaccination eligibilityNecrotising fasciitis / Fournier’s gangrene / gas gangreneNecrotizing Soft-Tissue InfectionOpportunistic infection overlay — HIV / transplant / biologic immunocompromisePediatric InfluenzaPertussis (whooping cough) — Bordetella pertussis — catarrhal + paroxysmal + convalescent phases + infant pertussis (apnea, pneumonia, pulmonary hypertension) + adult atypical + post-exposure prophylaxis + maternal Tdap at 27-36 wk every pregnancy + DTaP/Tdap vaccination schedule + cocooningPneumocystis jirovecii pneumonia (PJP/PCP)Pulmonary Tuberculosis (Drug-Susceptible)Sepsis / septic shockTetanus — generalized + localized + cephalic + neonatal forms + post-exposure prophylaxis (wound-stratified) + active Td/Tdap vaccination during convalescenceToxic Shock Syndrome (Staphylococcal & Streptococcal)Tuberculosis (active drug-susceptible, MDR-TB, LTBI)Varicella zoster virus disease — primary varicella + herpes zoster + PHN + complications + RZV vaccination eligibility

Nephrology

27 conditions

Neurology

54 conditions
Acute Disseminated Encephalomyelitis (ADEM)Acute Ischaemic StrokeAcute Transverse MyelitisAcute Traumatic Spinal Cord Injury (SCI)Acute Vestibular Syndrome (HINTS pivot for central vs peripheral)Adult tension-type headache (ICHD-3 diagnosis; EFNS 2010 treatment; SNNOOP10 red flags)Alzheimer Disease (outpatient + biomarker era)Aneurysmal SAH — Good Grade (Hunt-Hess I–III)Aneurysmal SAH — Poor Grade (Hunt-Hess IV–V)Anti-LGI1 EncephalitisAnti-NMDA Receptor EncephalitisBell Palsy (idiopathic peripheral facial palsy)Brain Abscess (Pyogenic)Cardioembolic Stroke (TOAST CE)Carpal tunnel syndrome (AAOS 2016 diagnosis + management; AANEM electrodiagnostics)Cauda Equina SyndromeCerebral Venous Sinus Thrombosis (CVST)Cluster HeadacheConvulsive Status EpilepticusDelirium (inpatient/ICU)First Unprovoked / New-Onset Seizure Evaluation (adult)Guillain-Barré SyndromeGuillain-Barré Syndrome — AIDP (classic demyelinating)Guillain-Barré Syndrome — AMAN (acute motor axonal)HSV Encephalitis (acute)Idiopathic Intracranial Hypertension (Pseudotumor Cerebri)Intracerebral HemorrhageIntracerebral Hemorrhage — Cerebellar (emergent decompression)Intracerebral Hemorrhage — Deep (hypertensive)Intracerebral Hemorrhage — Lobar (CAA-suspected)Large-Artery Atherosclerotic Stroke (TOAST LAA)Metastatic Spinal Cord Compression (MSCC)MigraineMiller-Fisher Syndrome (GBS variant)Multiple Sclerosis FlareMyasthenic CrisisMyelin Oligodendrocyte Glycoprotein-Antibody Associated Disease (MOGAD)Neuromyelitis Optica Spectrum Disorder (NMOSD)Non-aneurysmal Perimesencephalic SAHOther Autoimmune Encephalitis (surface + intracellular AB)Parkinson Disease (outpatient + chronic)Peripheral Neuropathy (distal symmetric polyneuropathy — DSPN; acquired-causes screen)Posterior Reversible Encephalopathy Syndrome (PRES)Primary Progressive Multiple SclerosisRelapsing-Remitting Multiple Sclerosis (chronic DMT)Restless Legs Syndrome / Willis–Ekbom DiseaseReversible Cerebral Vasoconstriction Syndrome (RCVS / Call-Fleming)Secondary Progressive Multiple SclerosisSmall-Vessel (Lacunar) Stroke (TOAST SVO)Spinal Cord Infarction (Anterior Spinal Artery Syndrome and other vascular cord lesions)Subarachnoid HemorrhageTransient Ischemic AttackTrigeminal Neuralgia (classic / secondary / idiopathic)Vascular Cognitive Impairment / Vascular Dementia

OB / GYN

32 conditions
Abnormal uterine bleeding (reproductive age — FIGO PALM-COEIN)Acute Fatty Liver of Pregnancy (AFLP)Amniotic Fluid Embolism (AFE)Bartholin gland cyst / abscess (I&D + Word catheter, marsupialization for recurrent)Breech Presentation at TermCervical Insufficiency (Painless 2nd-Trimester Cervical Dilation)Chorioamnionitis / Intra-amniotic Infection (IAI) / Triple IContraception management (US-MEC / US-SPR — method selection & comorbidity)Dysmenorrhoea (primary vs secondary — endometriosis-aware)Early Pregnancy Loss / MiscarriageEctopic pregnancy (tubal, interstitial, cornual, abdominal, cesarean-scar)Gestational diabetes (GDM)Gestational Diabetes Mellitus (A1 / A2 — OB perspective)Gestational Hypertension (without severe features)HELLP Syndrome (Hemolysis / Elevated Liver enzymes / Low Platelets)Hyperemesis GravidarumIntrahepatic Cholestasis of Pregnancy (ICP)Menopause & vasomotor-symptom management (MHT & non-hormonal)Ovarian / adnexal torsion (time-critical surgical emergency)Pelvic inflammatory disease (PID) + tubo-ovarian abscess (TOA)Peripartum Cardiomyopathy (PPCM)Placenta Previa & Placenta Accreta SpectrumPlacental Abruption / Abruptio PlacentaePostpartum Hemorrhage (PPH)Pre-eclampsia / Eclampsia / HELLPPre-eclampsia, Early-Onset (< 34 weeks gestational age)Preterm Labor (PTL) / Preterm Prelabor Rupture of Membranes (PPROM)Preterm Premature Rupture of Membranes (PPROM)Shoulder DystociaUterine Rupture (complete / incomplete dehiscence)Vaginitis (bacterial vaginosis / candidiasis / trichomoniasis)VTE in Pregnancy and Postpartum

Oncology

6 conditions

Pediatrics

35 conditions
Abusive head trauma / non-accidental trauma in infantsAcute appendicitis — pediatric (PAS-stratified; NOM-aware)Biliary atresiaBrief Resolved Unexplained Event (BRUE)Febrile infant (0-90 days)Infantile epileptic spasms syndrome (West syndrome)Infantile hypertrophic pyloric stenosis (IHPS)Intestinal malrotation with midgut volvulusIntussusception (ileocolic / ileoileal) — pediatricKawasaki diseaseMultisystem inflammatory syndrome in children (MIS-C)Necrotizing enterocolitis (NEC) — neonatal / preterm Bell-stagedNeonatal Abstinence Syndrome (NAS) / Neonatal Opioid Withdrawal Syndrome (NOWS)Neonatal Early-Onset Sepsis (EOS)Neonatal HSV (SEM, CNS, disseminated forms) — empiric acyclovir + form-specific durationNeonatal hyperbilirubinemia — kernicterus prevention (AAP 2022 thresholds)Neonatal HypoglycemiaNeonatal Hypoxic-Ischemic Encephalopathy (HIE)Neonatal Respiratory Distress Syndrome (RDS)Neonatal sepsis — early-onset (< 72 h) + late-onset (72 h - 28 d)Pediatric Acute Epiglottitis (Supraglottitis)Pediatric acute kidney injury (AKI)Pediatric asthma (chronic stepwise + acute exacerbation)Pediatric bacterial meningitisPediatric bronchiolitisPediatric community-acquired pneumoniaPediatric community-acquired pneumonia (CAP)Pediatric Croup (Laryngotracheobronchitis)Pediatric diabetic ketoacidosis (DKA)Pediatric head injury / mild TBI / concussion (PECARN-stratified)Pediatric sepsis / septic shockPediatric status epilepticusPediatric toxic ingestions (acute)Persistent Pulmonary Hypertension of the Newborn (PPHN)Reye syndrome

Psychiatry

22 conditions
Acute Agitation / Behavioral Emergency (ED) — de-escalation-first + chemical restraint (PO if cooperative / IM if not / ketamine rescue) + parallel underlying-cause workup (POC glucose ALWAYS) + post-sedation monitoring (Project BETA AAEP 2012; ACEP 2024 clinical policy; ADEPT Wilson 2017 PMID 28856060)Acute Alcohol Withdrawal — inpatient managementAcute Drug-Induced Dystonia & Extrapyramidal Syndromes — acute dystonia (oculogyric crisis / torticollis / trismus / opisthotonos / LARYNGEAL DYSTONIA = airway emergency) vs acute akathisia vs drug-induced parkinsonism after dopamine-antagonist exposure; IV/IM anticholinergic (benztropine 1-2 mg or diphenhydramine 25-50 mg) reversal + airway management if laryngeal + offending-agent management + propranolol-first-line akathisia + parkinsonism dose-reduction; RULE OUT NMS / serotonin syndrome (Pierre Drug Saf 2005 PMID 15733025; van Harten BMJ 1999 PMID 10463905)Acute OCD (Severe / Treatment-Resistant Exacerbation) — ED/inpatient acute stabilization + SRI high-dose + clomipramine adjunct + AP augmentation + ERP referral (APA OCD 2023; NICE CG31 2024; IOCDF 2025; PANS Consortium 2017 PMID 36358107)Alcohol use disorder — outpatient management + withdrawal risk (VA/DoD SUD 2021; APA 2018; DSM-5-TR)Anxiety Disorders (GAD / panic / social anxiety / specific phobia / agoraphobia) — chronic stepwise + acute panic (APA Panic 2009; NICE NG185 2024; CANMAT 2014 Katzman PMID 25081580)Attention-Deficit/Hyperactivity Disorder (ADHD) — chronic stepwise (AAP 2019 PMID 31570648; APA 2024; NICE NG87 2024; MTA 16-yr Hechtman PMID 27806862)Bipolar Disorder — acute mania + bipolar depression + maintenance (APA 2024; CANMAT/ISBD 2018; BALANCE Geddes Lancet 2010)Catatonia — transdiagnostic syndrome; lorazepam challenge + titration → ECT for refractory / malignant (DSM-5-TR 2022; Bush 1996 PMID 8686483; Sienaert 2014 PMID 25538636)Chronic insomnia disorder (AASM 2021 CBT-I; AASM 2017 pharmacotherapy; ACP 2016)Delirium — acute confusional state (DSM-5-TR 2022; SCCM PADIS 2018 PMID 30113379; NICE CG103 2010 reaffirmed 2024; CAM Inouye 2006 PMID 16540616; 4AT Bellelli 2014 PMID 24590568; MIND-USA Girard 2018 PMID 30346242)Eating Disorders (AN-R / AN-BP / BN / BED / ARFID / OSFED) — chronic stepwise + acute medical instability (APA 2023; AED 2016 Garber; NICE NG69 2023; Maudsley FBT Lock & Le Grange 2013; CBT-E Fairburn 2008)First-Episode Psychosis (FEP) — medical workup + low-dose antipsychotic + CSC (APA 2024; RAISE-ETP Kane AJP 2016)Major Depressive Disorder (MDD) — chronic stepwise + acute crisis (APA 2023; VA/DoD 2022)Neuroleptic Malignant Syndrome (NMS) — toxidrome from antipsychotic D2 blockade (Strawn AJP 2007 PMID 17541044; Levenson AJP 1985 PMID 2863986; DSM-5-TR 2022); STOP AP IMMEDIATELY + ICU + supportive (cooling + IV hydration) + dantrolene 1-2.5 mg/kg IV q6h + bromocriptine 2.5 mg PO TID + ECT for refractory; AVOID succinylcholine + re-introduction of offending AP + abrupt clozapine discontinuationOpioid Use Disorder — MOUD managementPostpartum depression — perinatal MDD (ACOG 757 2018/2024; USPSTF 2019; NICE NG192 2024; APA 2010 PPD; Meltzer-Brody 2018; Deligiannidis 2023)Postpartum psychosis — acute postpartum psychiatric emergency (ACOG 757 2018/2024; NICE NG192 2024; APA 2024; Bergink 2012; Sit 2006)PTSD (DSM-5-TR F43.10 acute / chronic / dissociative subtype + Acute Stress Disorder F43.0 + ICD-11 6B41 Complex PTSD) — trauma-focused psychotherapy first-line + SSRI/SNRI stepwise (APA 2017; VA/DoD 2023; NICE NG116 2024; ISTSS 2018)Serotonin syndrome — toxidrome from serotonergic exposure (Hunter 2003 PMID 12925718; Boyer NEJM 2005 PMID 15784664); STOP serotonergic + benzo + cyproheptadine + cooling; severe → ICU + intubation + paralysis (rocuronium); AVOID bromocriptine + succinylcholineSuicidality — ED risk assessment and dispositionTobacco use disorder / smoking cessation (USPSTF 2021; 2008 PHS Guideline; 2018 AHA/ACC; EAGLES)

Pulmonary

22 conditions

Rheumatology

24 conditions

Symptom-Led (ED)

31 conditions

Toxicology

17 conditions

Urology

24 conditions
Acute epididymitis ± orchitis (STI / enteric / viral / TB / drug / torsion-pivot DDx)Acute pyelonephritis (upper UTI; outpatient + inpatient + complicated + urosepsis)Acute scrotal pain — pivot / triage workup (routes to torsion / epididymitis / Fournier / urolithiasis / appendix testis)Benign Prostatic Hyperplasia (BPH) — chronic LUTS in adult menBenign prostatic hyperplasia / male LUTS (AUA 2023; EAU 2023; AUA/SUFU surgical 2020; AUA/SUFU OAB 2019)Catheter-Associated UTI (CAUTI) — indwelling / suprapubic / intermittent / long-termComplicated UTI (men, pregnant, catheter, anatomic, IC, ESBL/MDR, fungal, prostatitis overlay)Erectile dysfunction (AUA 2018; Princeton III 2012; a cardiovascular sentinel — assess & modify CV risk)Interstitial cystitis / bladder pain syndrome (IC/BPS) — AUA 2022 stepwise multimodal managementMale Infertility Evaluation — chronic outpatient (azoospermia / oligospermia / asthenospermia / teratospermia / varicocele / HH / drug-induced / radiation)Microscopic Hematuria Surveillance — chronic outpatient post-workup (AUA 2020 low / intermediate / high risk bands + IgA / Alport / sickle / anticoag / pediatric / schistosomiasis overlays)Nocturia — chronic outpatient evaluation (nocturnal polyuria / reduced bladder capacity / 24-h polyuria / sleep / med / BPH / CHF / CKD / pregnancy / aging)Pediatric UTI (neonate / infant / older child / adolescent; VUR, recurrent, dysfunctional voiding)Pediatric Vesicoureteral Reflux (VUR) — grade I–V; primary / secondary / antenatal-hydronephrosis pathway; prophylaxis / surgical / behavioural managementPost-Prostatectomy Complications (post-RP + TURP) — bleeding / stricture / incontinence / ED / lymphocele / DVT-PE / rectal injury / TURP syndromePriapism — urological emergency (ischemic / non-ischemic / stuttering / SCD-driven / drug-induced)Prostatitis spectrum (NIH I/II/IIIa/IIIb/IV) — acute bacterial + chronic + CP/CPPSRecurrent UTI Prophylaxis & Long-term Management (adult women + postmenopausal + breakthrough)Testicular torsion (time-critical scrotal emergency, <6 h salvage window)Uncomplicated UTI (acute cystitis, non-pregnant adult)Urethral Stricture Disease (bulbar / penile / pan-urethral / LSA / iatrogenic / post-traumatic / pediatric / bladder-neck-contracture)Urinary Incontinence — chronic outpatient evaluation (stress / urge / mixed / overflow / functional / continuous / pediatric / post-prostatectomy)Urolithiasis (kidney / ureteral stones)Varicocele (dilated pampiniform plexus veins; AUA/ASRM 2021; EAU 2021) — observation vs microsurgical varicocelectomy / embolization; RIGHT-sided or acute non-reducible = red flag for retroperitoneal/renal mass

Vascular

6 conditions