Heart failure in the frail older adult (chronic, sub-population)
Frail-elder HF chronic — tolerability-weighted GDMT (SGLT2i favored, DELIVER frailty subgroup) + STOPP/START deprescribing + orthostasis/falls mitigation + REHAB-HF rehab/nutrition + goals-of-care/palliative integration; deprescribe when harm > benefit. Completes the explicit STEP 3 list (sub-population variants). Manifest points at existing sibling cardio.acute-hf.core.v1.ts per nearest-ID precedent so the audit broken_pointers check passes; decision surface (tolerability-weighted + deprescribe + goals axis + workups + calculators + panels), test_files, 5-PMID evidence object (REHAB-HF/STOPP-START referenced by name — evidence-gap, not fabricated), chronic phases all present. Drug RxCUIs reused from RxNav-validated cardio dossiers (dapagliflozin 1488564, sacubitril/valsartan 1656340, bisoprolol 19484, spironolactone 9997, finerenone 2627043, furosemide 4603, midodrine 36117); assessment/deprescribe/rehab/palliative non_pharm; SNOMED deferred. 9 trigger/special-pop branches: iatrogenic-overtreatment (not-to-miss), severe-frailty goals, polypharmacy STOPP/START, orthostasis/falls, cognitive-impairment, sarcopenia/rehab, HFpEF-predominant, CKD-limiting, AF-AC-balance.
Entry points (5)
- problem_listHeart failure in a frail older adult (HFpEF-predominant)hf_in_frail_elder
- symptomGDMT intolerance / symptomatic hypotension / falls on HF medsgdmt_intolerance_hypotension
- medicationHigh polypharmacy burden with HF regimenpolypharmacy_burden
- symptomRecurrent falls / orthostatic hypotensionfalls_orthostasis
- historyGoals-of-care / palliative review in advanced HF + frailtygoals_of_care_review
Required inputs (10)
- agerequireddemographic • used at CONTEXTOlder-adult HF management + prognosis framing
- hf_phenotyperequiredimaging • used at FRAMEHFpEF (predominant in elderly) vs HFrEF/HFmrEF — GDMT intensity
- frailty_severityrequiredhistory • used at RISK_STRATIFICATIONClinical Frailty Scale — drives disease-modifying vs symptom-focused intensity
- current_medsrequiredmedication • used at CONTEXTPolypharmacy + STOPP/START deprescribing targets
- orthostatic_bprequiredvital • used at TREATMENTOrthostatic hypotension gates RAS/BB titration + diuretic dosing
- renal_functionrequiredlab • used at TREATMENTeGFR limits GDMT; over-diuresis pre-renal/falls
- cognitive_statushistory • used at CONTEXTCognitive impairment → adherence aids, caregiver, regimen simplification
- falls_historyhistory • used at RISK_STRATIFICATIONFalls risk modifies BP target + drug choices
- functional_status_goalsrequiredsymptom • used at RISK_STRATIFICATIONFunction + patient goals (what Matters) → care intensity
- creatininerequiredlab • used at TREATMENTRenal drug dosing
12-phase flow (12)
- 1FRAMEHF phenotype + frailty severity + patient goals — set disease-modifying vs symptom-focused frameinputs: hf_phenotypeadvance: phenotype + frailty + goals framed
- 2ENTRYHF in frail elder, GDMT intolerance, polypharmacy, falls/orthostasis, goals reviewinputs: ageadvance: entry trigger captured
- 3CONTEXTMultimorbidity, cognition, function, caregiver/SDOH, medication burdeninputs: current_meds, cognitive_statusadvance: geriatric context complete
- 4RED_FLAGSDecompensation; iatrogenic harm — symptomatic hypotension/AKI/falls from over-treatmentinputs: orthostatic_bp, renal_functionactions: cardiogenic_shock, acute_pulm_edemaadvance: no red flags or routed/iatrogenic harm addressed
- 5INITIAL_WORKUPEcho phenotype, BMP, orthostatic BP, frailty + cognition screeninputs: orthostatic_bp, renal_functionactions: panel.cardiac, panel.renaladvance: phenotype + frailty + safety metrics documented
- 6BRANCHING_WORKUPClinical Frailty Scale, nutrition/sarcopenia, polypharmacy (STOPP/START) review, prognosis estimationinputs: frailty_severityactions: preop_cardiacadvance: frailty + polypharmacy + prognosis characterised
- 7DIFFERENTIALHF phenotype; frailty/competing-morbidity-driven vs cardiac-driven symptomsinputs: hf_phenotype, frailty_severityadvance: symptom attribution + phenotype assigned
- 8RISK_STRATIFICATIONFrailty + prognosis + goals → disease-modifying vs symptom-focused intensityinputs: frailty_severity, functional_status_goalsadvance: care intensity + goals tier assigned
- 9TREATMENTTolerability-weighted GDMT (SGLT2i favored) + STOPP/START deprescribing + orthostasis/falls mitigation + nutrition/REHAB-HF rehab + goals-aligned palliative integrationinputs: orthostatic_bp, renal_function, current_medsadvance: tolerability-weighted plan + deprescribing + goals alignment documented
- 10DISPOSITIONGeriatric-cardiology co-management; palliative referral when goals-alignedinputs: functional_status_goalsactions: preop_cardiacadvance: co-management/palliative plan set
- 11MONITORINGOrthostatic BP, renal/K, falls, function, medication burden — de-escalate if harm > benefitinputs: orthostatic_bp, renal_functionactions: panel.renaladvance: monitoring cadence documented
- 12FOLLOWUPPeriodic goals-of-care re-evaluation; caregiver support; re-phenotype if HF changesinputs: functional_status_goalsadvance: goals re-evaluation + caregiver plan documented