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ent.tonsillitis-recurrent.core.v1

Recurrent tonsillitis & tonsillectomy candidacy (Paradise criteria, AAO-HNSF 2019 update)

general_internal_medicinechronicsubacutepediatricadultoutpatienttransition

Longitudinal tonsillectomy-candidacy engine — companion to ent.pharyngitis.core.v1 which owns the per-episode antibiotic decision. Two jobs: (A) verify Paradise criteria with documentation against AAO-HNSF 2019 watchful-waiting bias; (B) recognise modifying factors (PFAPA, recurrent PTA, multiple antibiotic allergies, OSA — separate pathway) and red-flag mimics (tonsillar asymmetry, B symptoms, infectious mononucleosis). Per-episode dosing recapped for documentation completeness but is OWNED by the acute pharyngitis engine. RxCUI status (RxNav-verified live 2026-05-26, ingredient TTY confirmed): penicillin V 7984, amoxicillin 723, cephalexin 2231, clindamycin 2582, azithromycin 18631, dexamethasone 3264, ibuprofen 5640, acetaminophen 161. Tonsillectomy procedure and watchful-waiting decision are non-pharm entries (procedure / longitudinal-decision, no dispensed-drug RxCUI required). PMID status (live PubMed-verified 2026-05-26): 30798778 = Mitchell AAO-HNSF Tonsillectomy CPG Update OHNS 2019 (full); 30921525 = Mitchell AAO-HNSF Executive Summary OHNS 2019; 6700642 = Paradise NEJM 1984 (severely-affected children, Paradise criteria); 12093941 = Paradise Pediatrics 2002 (moderately-affected, modest benefit only). The originally supplied PMID 30798751 in upstream prompt was a paper on opioid-dependence / bariatric Roy Adaptation Model, fabricated/misattributed — corrected to 30798778 and 30921525 (the actual AAO-HNSF 2019 update). Key clinical anchors: (1) AAO-HNSF 2019 STRONG RECOMMENDATIONS — watchful waiting if Paradise not met; intraoperative IV dexamethasone if proceeding; ibuprofen + acetaminophen for post-op pain; AGAINST routine perioperative antibiotics; AGAINST codeine in <12y; overnight inpatient monitoring for <3y or severe OSA; document primary + secondary bleeding annually. (2) Tonsillectomy is an OPTION (not strong recommendation) even when Paradise met, with shared decision-making mandatory. (3) Paradise Pediatrics 2002 (PMID 12093941) showed modest benefit decay in moderately-affected children — strict Paradise thresholds matter. (4) PFAPA tonsillectomy can be curative — distinct pathway. (5) OSA tonsillectomy is a separate AAO-HNSF 2019 pathway with polysomnography prerequisites. Clinical-uncertainty notes: (1) The watchful-waiting recommendation is grounded in evidence that many moderately-affected children spontaneously regress; the engine prevents over-tonsillectomy by demanding documentation. (2) AAO-HNSF 2019 deals primarily with pediatric tonsillectomy; adult tonsillectomy uses analogous Paradise reasoning but has less RCT-quality evidence. (3) Pregnancy: defer elective tonsillectomy; per-episode antibiotic safety is amoxicillin / penicillin V class B/A and unrestricted; tetracyclines avoided. (4) Terminology codes are canonical adult / pediatric tonsillitis ICD-10-CM but ⚠ per memory terminology pipeline is partial — flagged for scripts/terminology revalidation.

Entry points (6)

  • history
    Patient with documented recurrent throat infections — ≥3 episodes/year for ≥2-3 years OR ≥5/year for 2 years OR ≥7 in past year (Paradise criteria, established Paradise NEJM 1984 PMID 6700642; reaffirmed AAO-HNSF 2019 Mitchell PMID 30798778)
    documented_recurrent_throat_infections_paradise_candidate
  • history
    Regular periodic fevers + aphthous stomatitis + pharyngitis + cervical adenitis pattern in a child — PFAPA / Marshall syndrome entry; tonsillectomy can be curative (AAO-HNSF 2019 PMID 30798778)
    periodic_fever_aphthous_pharyngitis_adenitis_pattern
  • history
    History of ≥1 peritonsillar abscess (quinsy) — AAO-HNSF 2019 modifying factor that may favour tonsillectomy without strict Paradise
    prior_peritonsillar_abscess
  • history
    Multiple antibiotic allergies / intolerance limiting GAS treatment — AAO-HNSF 2019 modifying factor
    multiple_antibiotic_allergies_intolerance
  • symptom
    Asymmetric tonsillar enlargement, unilateral mass, ipsilateral cervical lymphadenopathy, B symptoms (weight loss, night sweats) — malignancy work-up entry (lymphoma, head/neck SCC), recognise and route OUT
    tonsillar_asymmetry_unilateral_mass_b_symptoms
  • history
    Patient or caregiver request for tonsillectomy evaluation regardless of episode count — opportunity for shared decision-making against the AAO-HNSF 2019 watchful-waiting recommendation
    parent_or_patient_request_for_tonsillectomy_evaluation

Required inputs (15)

  • episode_count_with_documentation_year_1required
    history • used at ENTRY
    Number of documented sore-throat episodes in the past 12 months — the year-1 Paradise threshold is ≥7. Documentation is required: AAO-HNSF 2019 demands sore throat + ≥1 of (T>38.3°C, cervical adenopathy, tonsillar exudate, positive GAS test) per episode (Mitchell PMID 30798778)
  • episode_count_with_documentation_years_1_2required
    history • used at CONTEXT
    Annual episode count for the past 2 years — the year-2 Paradise threshold is ≥5/year for 2 years (Paradise NEJM 1984 PMID 6700642)
  • episode_count_with_documentation_years_1_2_3required
    history • used at CONTEXT
    Annual episode count for the past 3 years — the year-3 Paradise threshold is ≥3/year for 3 years (Paradise NEJM 1984 PMID 6700642)
  • documentation_quality_per_episoderequired
    history • used at ENTRY
    Each counted episode MUST be documented as sore throat + ≥1 objective criterion (T>38.3°C / cervical adenopathy / tonsillar exudate / positive GAS test / prior antibiotic for GAS). Undocumented episodes do NOT count toward Paradise threshold (AAO-HNSF 2019 Mitchell PMID 30798778)
  • agerequired
    demographic • used at CONTEXT
    Age governs anaesthetic risk, perioperative bleeding risk, codeine contraindication (<12 years), and overnight-monitoring requirement (<3 years or severe OSA) (AAO-HNSF 2019 Mitchell PMID 30798778)
  • modifying_factor_pfapa_pattern
    history • used at DIFFERENTIAL
    Regular monthly fever spikes + aphthous stomatitis + pharyngitis + cervical adenitis = PFAPA / Marshall syndrome; tonsillectomy is curative in many cases — distinct pathway from classical recurrent GAS (AAO-HNSF 2019 Mitchell PMID 30798778)
  • modifying_factor_prior_peritonsillar_abscess
    history • used at RISK_STRATIFICATION
    ≥1 peritonsillar abscess is an AAO-HNSF 2019 modifying factor that can shift the threshold even without meeting strict Paradise (Mitchell PMID 30798778)
  • modifying_factor_multiple_antibiotic_allergies
    history • used at RISK_STRATIFICATION
    Multiple antibiotic allergies / intolerance is an AAO-HNSF 2019 modifying factor (Mitchell PMID 30798778)
  • red_flag_tonsillar_asymmetry_or_b_symptomsrequired
    symptom • used at RED_FLAGS
    Unilateral tonsillar enlargement, mass, ipsilateral persistent adenopathy, B symptoms (weight loss, night sweats, fevers without infection) — malignancy work-up (lymphoma, head/neck SCC) takes priority; route OUT (clinical)
  • red_flag_obstructive_sleep_apnea_featuresrequired
    symptom • used at CONTEXT
    Loud habitual snoring, witnessed apnoeas, daytime hypersomnolence — obstructive sleep apnoea / sleep-disordered breathing is a SEPARATE tonsillectomy indication on its own pathway (AAO-HNSF 2019 Mitchell PMID 30798778); polysomnography is required pre-op in defined subgroups
  • penicillin_allergy
    history • used at CONTEXT
    Per-episode antibiotic regimen gating (penicillin V / amoxicillin first-line, cephalexin if non-anaphylactic, clindamycin / azithromycin if severe) — per-episode dosing OWNED by ent.pharyngitis.core.v1; documented here as a tonsillectomy-modifying factor (multiple antibiotic allergies)
  • medical_comorbidities_bleeding_risk_anaesthesia_riskrequired
    history • used at CONTEXT
    Bleeding diathesis (vWF, haemophilia, antiplatelet/anticoagulant use), syndromic / craniofacial anomalies, cardiac disease, severe asthma, OSA-related comorbidities — all alter perioperative risk and inform shared-decision-making (AAO-HNSF 2019 Mitchell PMID 30798778)
  • pregnancy
    history • used at TREATMENT
    Pregnancy gates per-episode antibiotic safety (penicillin/amoxicillin safe, tetracyclines avoided) and defers elective tonsillectomy when possible
  • rapid_strep_radt
    lab • used at INITIAL_WORKUP
    Per-episode RADT confirms GAS — required at each episode to count it toward Paradise documentation; per-episode treatment is OWNED by ent.pharyngitis.core.v1 (IDSA 2012 Shulman PMID 22965026)
  • throat_culture_back_up
    lab • used at INITIAL_WORKUP
    Back-up throat culture after negative RADT in children/adolescents per IDSA 2012 (higher ARF risk in this population); supports documentation per episode (AAO-HNSF 2019 Mitchell PMID 30798778)

12-phase flow (12)

  1. 1FRAME
    Frame as a LONGITUDINAL tonsillectomy-candidacy engine — NOT a per-episode antibiotic engine (ent.pharyngitis.core.v1 owns the acute episode). Two jobs: (A) decide whether the patient meets Paradise criteria with adequate documentation, with watchful-waiting bias per AAO-HNSF 2019 (Mitchell PMID 30798778); (B) identify modifying factors and red-flag mimics (PFAPA, malignancy, OSA) that change the pathway.
    advance: longitudinal scope confirmed; per-episode antibiotic decisions routed to ent.pharyngitis.core.v1
  2. 2ENTRY
    Verify the documented episode count meets a Paradise threshold (year-1 ≥7, year-2 ≥5/y × 2, or year-3 ≥3/y × 3) AND each episode has the required objective documentation. Episodes without documentation do NOT count — common error in real-world practice and the most frequent reason a patient appears Paradise-positive but is not (Paradise NEJM 1984 PMID 6700642; AAO-HNSF 2019 Mitchell PMID 30798778).
    inputs: episode_count_with_documentation_year_1, documentation_quality_per_episode
    advance: Paradise threshold and documentation gates evaluated explicitly
  3. 3CONTEXT
    Build the longitudinal context: 2-year and 3-year episode counts, age (affects anaesthetic / overnight-monitoring / codeine restrictions), comorbidities (bleeding risk, OSA features, cardiac, syndromic), penicillin-allergy profile. OSA features always flagged — OSA tonsillectomy is a separate AAO-HNSF 2019 pathway.
    inputs: episode_count_with_documentation_years_1_2, episode_count_with_documentation_years_1_2_3, age, red_flag_obstructive_sleep_apnea_features, penicillin_allergy, medical_comorbidities_bleeding_risk_anaesthesia_risk
    advance: longitudinal episode + age + comorbidity + OSA context captured
  4. 4RED_FLAGS
    Recognise (do NOT manage here): asymmetric tonsillar enlargement / unilateral mass / B symptoms → malignancy work-up (lymphoma, head/neck SCC); acute peritonsillar abscess → ent.peritonsillar-abscess.core.v1; sepsis / Lemierre with current acute episode → id.sepsis.core.v1; airway compromise from acute episode or perioperative complication → emergent airway. Post-tonsillectomy haemorrhage is a known complication and a return-precaution.
    inputs: red_flag_tonsillar_asymmetry_or_b_symptoms
    actions: workup.airway_distress, calc.qsofa
    advance: malignancy / abscess / sepsis / airway red flags screened and routed if positive
  5. 5INITIAL_WORKUP
    Confirm GAS at each documented episode (RADT, with back-up culture in children per IDSA 2012); collect documentation (date, symptom + objective criterion + treatment) into a longitudinal log. AAO-HNSF 2019 strongly discourages routine perioperative antibiotics. Pre-tonsillectomy polysomnography is required for children <2 y or with obesity / Down syndrome / craniofacial / neuromuscular / sickle / mucopolysaccharidoses, and is recommended for any child where the need for tonsillectomy is uncertain or discordant with exam (Mitchell PMID 30798778).
    inputs: rapid_strep_radt, throat_culture_back_up
    actions: panel.cbc, panel.inflammation
    advance: per-episode GAS confirmation and longitudinal log built; polysomnography ordered if OSA pathway
  6. 6BRANCHING_WORKUP
    Branch on pattern: regular monthly fever + aphthous + pharyngitis + adenitis → PFAPA (consider IL-1 axis pathway / specialist immunology) — tonsillectomy can be curative; tonsillar asymmetry / B symptoms → ENT urgent referral for biopsy (lymphoma / SCC); OSA features → polysomnography + AAO-HNSF 2019 OSA tonsillectomy pathway; recurrent peritonsillar abscess → tonsillectomy modifying factor
    inputs: modifying_factor_pfapa_pattern, modifying_factor_prior_peritonsillar_abscess
    actions: workup.lymphadenopathy
    advance: PFAPA / OSA / malignancy / abscess branches assigned and routed if needed
  7. 7DIFFERENTIAL
    Terminal differential: classical recurrent GAS tonsillitis meeting Paradise (treat or watchful-wait per AAO-HNSF 2019) vs Paradise-not-met / sub-threshold (watchful waiting recommended) vs PFAPA (regularity + aphthous + adenitis pivot — tonsillectomy can be curative) vs OSA / sleep-disordered breathing (snoring + apnoeas + polysomnography pivot — separate tonsillectomy pathway) vs streptococcal carrier (asymptomatic positive culture — do NOT treat or operate) vs malignancy (asymmetry / mass / B symptoms — biopsy pathway) vs infectious mononucleosis (longer fatigue + posterior nodes + splenomegaly — different pathway). The chosen pathway drives the next step.
    advance: single best pathway chosen; sub-threshold cases held for watchful waiting
  8. 8RISK_STRATIFICATION
    Stratify tonsillectomy candidacy: STRONG (meets Paradise with adequate documentation AND symptomatic burden / time-off-school-work AND failed watchful-waiting OR has PFAPA / OSA / recurrent PTA) vs MODERATE (modifying factors present but Paradise not strictly met — shared decision) vs WEAK (Paradise not met, no modifying factor — AAO-HNSF 2019 RECOMMENDS WATCHFUL WAITING). Layer perioperative risk: bleeding diathesis, age <3 y or severe OSA (overnight admission required), codeine contraindication <12 y.
    inputs: modifying_factor_prior_peritonsillar_abscess, modifying_factor_multiple_antibiotic_allergies, medical_comorbidities_bleeding_risk_anaesthesia_risk
    advance: candidacy band assigned with perioperative-risk layered
  9. 9TREATMENT
    Per-episode antibiotic regimen for confirmed GAS is OWNED by ent.pharyngitis.core.v1 (penicillin V / amoxicillin first-line × 10 days; benzathine penicillin G 1.2 MU IM single dose; cephalexin if non-anaphylactic penicillin allergy; clindamycin / azithromycin if severe). Symptomatic care every episode (analgesia, hydration; single-dose dexamethasone for severe odynophagia is an option). LONGITUDINAL decision: AAO-HNSF 2019 strong recommendation = WATCHFUL WAITING if Paradise not met; tonsillectomy is an OPTION (not recommendation) when met. Post-tonsillectomy: single intraoperative IV dexamethasone (AAO-HNSF 2019 strong recommendation); ibuprofen + acetaminophen for pain control (AAO-HNSF 2019 strong recommendation); NO codeine in children <12 years (AAO-HNSF 2019 strong recommendation against); NO routine perioperative antibiotics (AAO-HNSF 2019 strong recommendation against).
    inputs: penicillin_allergy, pregnancy
    advance: per-episode regimen routed to ent.pharyngitis; longitudinal candidacy decision documented; perioperative bundle ordered if proceeding
  10. 10DISPOSITION
    OUTPATIENT clinic-based longitudinal management is the default. Inpatient overnight monitoring REQUIRED post-tonsillectomy for: age <3 years; severe OSA (AHI ≥10 obstructive events/h, SpO2 nadir <80%, or both); other significant comorbidity. Same-day discharge appropriate for older healthy patients. Acute peritonsillar abscess or sepsis with the current episode → admit and route OUT (Mitchell PMID 30798778).
    inputs: age, red_flag_obstructive_sleep_apnea_features
    advance: disposition documented; inpatient-monitoring criteria explicitly applied to post-op cases
  11. 11MONITORING
    Pre-tonsillectomy longitudinal: track episodes, documentation quality, and patient-reported burden (school/work absence, QoL); reassess at 6-12 months — many sub-threshold patients regress to fewer episodes naturally. Post-tonsillectomy: assess primary (<24 h) and secondary (>24 h) bleeding rates per individual surgeon (AAO-HNSF 2019 requires annual measurement). Post-op pain control reassessment 24-72 h. Counsel that obstructive sleep-disordered breathing MAY persist or recur post-tonsillectomy (Mitchell PMID 30798778).
    inputs: documentation_quality_per_episode
    advance: longitudinal episode-tracking documented; post-op recovery reviewed
  12. 12FOLLOWUP
    Pre-op: 6-12 monthly review with formal episode-and-documentation re-count; shared-decision conversation each visit. Post-op: review at 2-3 weeks for haemorrhage / hydration / pain (peak secondary bleed window day 5-10), at 6-8 weeks for symptom resolution + OSA re-evaluation (recurrence possible). Document primary + secondary bleeding outcome in medical record (AAO-HNSF 2019 requirement). Long-term: counsel that tonsillectomy benefit decays beyond 12 months in the moderately-affected group (Paradise Pediatrics 2002 PMID 12093941).
    inputs: documentation_quality_per_episode
    advance: structured longitudinal review + post-op bleeding-outcome documentation completed