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Patient handout

Acute Infectious Gastroenteritis / Acute Diarrhoea (viral, bacterial incl. invasive/inflammatory, traveller's, toxin food poisoning, C. difficile pointer) — adult + pediatric

PRODUCTION

1. Your condition

This handout is for acute infectious gastroenteritis / acute diarrhoea (viral, bacterial incl. invasive/inflammatory, traveller's, toxin food poisoning, c. difficile pointer) — adult + pediatric. Your care team identified this based on: acute diarrhoea (≤14 d, usually <7) ± nausea/vomiting (idsa 2017 pmid 29053792; acg 2016 pmid 27068718).

Other reasons your team may use this plan: bloody / mucoid (dysenteric) stool ± fever ± tenesmus — invasive/inflammatory bacterial pivot (idsa 2017 pmid 29053792); fever + diarrhoea — inflammatory/invasive or systemic enteric infection (idsa 2017 pmid 29053792); vomiting-predominant short-incubation illness after shared meal — preformed-toxin food poisoning (acg 2016 pmid 27068718).

2. Your medications

Take these medications exactly as prescribed. Do not stop or change a dose without talking to your provider.

MedicationStarting doseHowWhenWhat it does
reduced_osmolarity_oral_rehydration_saltsReduced-osmolarity ORS — replace deficit (mild ~50 mL/kg, moderate ~100 mL/kg over 3-4 h) + ongoing losses (~10 mL/kg per stool) + maintenancePOcontinuous, frequent small volumesReduced-osmolarity ORS is the cornerstone for mild-moderate dehydration — fewer unscheduled IV infusions (OR 0.61, 95% CI 0.47-0.81), less stool output and vomiting vs standard ORS (Hahn BMJ 2001 / Cochrane CD002847 PMID 11869639; ESPGHAN/ESPID 2014 PMID 24739189). No single RxNorm CUI → non_pharm.
iv_isotonic_crystalloid_rehydrationIsotonic crystalloid (LR or NS); peds 20 mL/kg boluses to reverse shock then deficit + maintenance; adult 30 mL/kg if septic/shock then titrateIVbolus then maintenanceIV isotonic crystalloid for severe dehydration/shock or ORS failure (IDSA 2017 PMID 29053792; ESPGHAN/ESPID 2014 PMID 24739189)
early_refeeding_continue_breastfeedingResume age-appropriate diet within 4-6 h of rehydration; continue breastfeeding throughout; no dietary dilution/restrictionPOcontinuousEarly refeeding shortens illness; do NOT withhold food or interrupt breastfeeding (ESPGHAN/ESPID 2014 PMID 24739189)
zinc_sulfate10 mg/day (<6 mo) or 20 mg/day (≥6 mo) PO × 10-14 daysPOonce dailyWHO/UNICEF — zinc reduces diarrhoea duration/severity and recurrence in children in low-resource settings (ESPGHAN/ESPID 2014 PMID 24739189)

Plan: Acute gastroenteritis management — rehydration + selective antimicrobial + antiemetic (IDSA 2017 PMID 29053792 + ACG 2016 PMID 27068718 + ISTM/IDSA 2017 PMID 28521004 + ESPGHAN/ESPID 2014 PMID 24739189 + WHO ORS PMID 11869639)

3. When to call your provider

Contact your care team if any of the following happen:

  • Severe dehydration / shock / lethargy → ED for IV resuscitation
  • Bloody diarrhoea + high fever / dysentery → ED + stool studies
  • Suspected STEC (bloody, low/no fever, decreasing urine, pallor) → ED + HUS workup (avoid abx/antimotility)
  • Intractable vomiting unresponsive to a dose of ondansetron → ED

4. When to seek emergency care

Call 911 or go to the nearest emergency room right away if you have:

  • Severe dehydration (≥10% peds weight loss / lethargy, sunken eyes, absent tears, prolonged capillary refill, weak pulse) or hypotension/orthostatic shock (ESPGHAN/ESPID 2014 PMID 24739189; IDSA 2017 PMID 29053792)(life-threatening)
  • Bloody/mucoid (dysenteric) stool + high fever ± severe abdominal pain/tenesmus — invasive bacterial enteritis (IDSA 2017 PMID 29053792)
  • Bloody diarrhoea with little/no fever ± abdominal pain ± oliguria/pallor — suspected Shiga-toxin E. coli / evolving HUS (Wong NEJM 2000 PMID 10874060)(life-threatening)
  • Invasive enteric infection with qSOFA/SIRS positivity + hypotension despite fluids + lactate >2 mmol/L (Sepsis-3; IDSA 2017 PMID 29053792)(life-threatening)
  • Rising creatinine / oliguria from volume depletion (or STEC-HUS) during acute gastroenteritis (KDIGO; Wong NEJM 2000 PMID 10874060)
  • Acute gastroenteritis in HIV/transplant/chemotherapy/biologic-immunosuppressed host (IDSA 2017 PMID 29053792)

5. Follow-up

Most: complete recovery, return precautions, hygiene/food-safety counselling, no routine test-of-cure; public-health reporting + food-handler clearance for reportable pathogens; persistent/post-infectious symptoms → reassess (post-infectious IBS — gi.ibs.core.v1; persistent → chronic-diarrhoea workup); rotavirus-vaccine context (pediatric) (IDSA 2017 PMID 29053792; ACG 2016 PMID 27068718)

6. Sources

Guideline: IDSA 2017 Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea (Shane, Clin Infect Dis 2017) + ACG 2016 Acute Diarrheal Infections in Adults (Riddle, Am J Gastroenterol 2016) + ISTM/IDSA 2017 Travelers' Diarrhea graded expert panel (Riddle, J Travel Med 2017) + ESPGHAN/ESPID 2014 pediatric AGE (Guarino, JPGN 2014) + WHO/UNICEF reduced-osmolarity ORS + zinc

  1. pubmed.ncbi.nlm.nih.gov/29053792
  2. pubmed.ncbi.nlm.nih.gov/27068718
  3. pubmed.ncbi.nlm.nih.gov/28521004