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Patient handout

Gastroparesis

PRODUCTION

1. Your condition

This handout is for gastroparesis. Your care team identified this based on: chronic nausea, vomiting, early satiety, post-prandial fullness (≥3 months) (acg 2022).

Other reasons your team may use this plan: unexplained chronic vomiting + diabetes (acg 2022); 4-hour gastric emptying scintigraphy with >10% retention at 4h (acg 2022 gold standard); post-surgical (fundoplication, gastric/bariatric) or post-viral gp (acg 2022).

2. Your medications

Take these medications exactly as prescribed. Do not stop or change a dose without talking to your provider.

MedicationStarting doseHowWhenWhat it does
dietary_modificationSmall frequent (5-6/day) low-fat low-fiber meals; soft / liquid-blended consistency during flares; chew thoroughlyPOmealsACG 2022 — dietary modification is first-line for all GP patients
optimize_glycemic_controlA1c <7-8% per ADA + GP context; avoid hyperglycemia >180 (acutely worsens emptying)PO/SCcontinuousACG 2022 — hyperglycemia acutely worsens gastric emptying; tight control improves symptoms
discontinue_offending_medsDiscontinue or substitute opioids, GLP-1 agonists (semaglutide / tirzepatide), anticholinergics, TCAs where possiblePO/SCone_timeACG 2022 — drug-induced GP common and reversible
hydration_electrolyte_replacementPO if tolerated; IV if severePO/IVcontinuousACG 2022 — common in moderate-severe GP

Plan: Gastroparesis tiered management — diet + glycemic + prokinetic + antiemetic + endoscopic / surgical (ACG 2022)

3. When to call your provider

Contact your care team if any of the following happen:

  • Severe dehydration or electrolyte disturbance → ED / inpatient (ACG 2022)
  • >10% weight loss → nutrition + consider enteral feeding (ACG 2022)
  • Refractory disease → G-POEM / GES evaluation (ACG 2022)
  • Suspected tardive dyskinesia → discontinue metoclopramide + neurology (ACG 2022)

4. When to seek emergency care

Call 911 or go to the nearest emergency room right away if you have:

  • Severe vomiting with dehydration, hypokalemic hypochloremic metabolic alkalosis, or AKI (ACG 2022)
  • New oral / facial / limb dyskinesia on metoclopramide (ACG 2022 FDA black-box)
  • Weight loss >10% baseline, albumin <3.0, BMI <18 (ACG 2022)
  • QTc >500 ms on metoclopramide / domperidone / erythromycin (ACG 2022)

5. Follow-up

q1-3 mo while titrating; q6 mo stable; nutrition + diabetes coordination; psychiatric / quality-of-life support; discontinue metoclopramide by 12 weeks or when tardive dyskinesia signs (ACG 2022)

6. Sources

Guideline: ACG 2022 Clinical Guideline: Gastroparesis (Camilleri M et al, Am J Gastroenterol 2022)

  1. pubmed.ncbi.nlm.nih.gov/35926490
  2. pubmed.ncbi.nlm.nih.gov/36397928