This handout is for acute traumatic spinal cord injury (sci). Your care team identified this based on: blunt trauma (mvc / fall / sports) with focal motor or sensory deficit (aans/cns 2013 pmid 23839357).
Other reasons your team may use this plan: penetrating neck / back injury (gsw / stab) with focal deficit (aans/cns 2013 pmid 23839357); high cervical (c3-c5 phrenic involvement) injury with diaphragm paralysis / respiratory failure → stat intubation (aans/cns 2013 pmid 23839357); neurogenic shock — hypotension + relative bradycardia + warm peripheries above t6 (karsy/hawryluk curr neurol neurosci rep 2019 pmid 31363857).
Take these medications exactly as prescribed. Do not stop or change a dose without talking to your provider.
| Medication | Starting dose | How | When | What it does |
|---|---|---|---|---|
| norepinephrine | 0.05-0.1 mcg/kg/min IV titrate to MAP ≥85 mmHg (typical adult start 5-10 mcg/min) | IV | continuous infusion | Norepinephrine preferred first-line vasopressor in acute SCI for combined alpha + mild beta support (treats both vasoplegia and relative bradycardia of high cord injuries) per Karsy/Hawryluk Curr Neurol Neurosci Rep 2019 (PMID 31363857); Hawryluk MAP-recovery doctrine (PMID 25669633) |
| phenylephrine | 0.5-1 mcg/kg/min IV (typical adult start 40-100 mcg/min); push-dose 50-200 mcg IV for transient hypotension | IV | continuous infusion | Pure alpha-agonist alternative when tachyarrhythmia limits norepinephrine; can worsen bradycardia of high cervical injury — monitor for reflex bradycardia (AANS/CNS 2013 PMID 23839357) |
Plan: Acute SCI secondary-injury-prevention bundle: MAP ≥85 × 7 d + early decompression + DVT prophylaxis + spasticity + autonomic-dysreflexia (AANS/CNS 2013 PMID 23839357 + Fehlings AOSpine 2017 PMIDs 29164026/29164028/29164029 + Fehlings AOSpine 2024 update PMID 38526922 + Hawryluk PMID 25669633)
Use these zones to know what to do based on how you feel.
Call 911 or go to the nearest emergency room right away if you have:
SCI rehab centre referral; long-term complications: autonomic dysreflexia (T6+), neurogenic bladder, neurogenic bowel, pressure injury, spasticity, heterotopic ossification, mood/cognition, sexuality/fertility, vocational; lifelong management (Fehlings AOSpine 2017 rehab PMID 29164029)
Guideline: AANS/CNS 2013 Guidelines for the Management of Acute Cervical Spine and Spinal Cord Injuries (Walters/Hadley, Neurosurgery 2013) + AOSpine/AANS-CNS 2017 Joint Guidelines (Fehlings, Global Spine J) + AOSpine 2024 Update on Timing of Decompressive Surgery (Fehlings, Global Spine J 2024)