This handout is for suicidality — ed risk assessment and disposition. Your care team identified this based on: suicidal ideation (passive or active) on presentation or screening (posner 2011 pmid 22193671; joint commission npsg 2024).
Other reasons your team may use this plan: recent suicide attempt — overdose, lacerations, hanging, firearm, other method (apa 2003 pmid 14627059; va/dod 2019); recent self-harm behavior with or without suicidal intent (posner 2011 pmid 22193671); phq-9 item 9 score ≥1 on routine screening (any setting) (kroenke jgim 2001).
Take these medications exactly as prescribed. Do not stop or change a dose without talking to your provider.
| Medication | Starting dose | How | When | What it does |
|---|---|---|---|---|
| lithium | 300 mg PO BID — target level 0.6–0.8 mmol/L (suicide reduction may be present at lower levels) | PO | BID with level monitoring | Cipriani BMJ 2013 NMA — lithium reduces suicide attempts and completed suicide in both unipolar and bipolar; baseline renal + thyroid + pregnancy considerations; initiation in inpatient or specialty outpatient setting, not ED |
| clozapine | 12.5 mg PO daily — slow titration per REMS | PO | daily titration | InterSePT — clozapine reduced suicide attempts vs olanzapine in schizophrenia + schizoaffective; REMS with weekly ANC × 6 mo then biweekly × 6 mo then monthly; not initiated in ED |
| esketamine | 84 mg intranasal (per ASPIRE protocol for SI indication) | intranasal | twice weekly × 4 weeks induction (in select centers; SPRAVATO REMS) | ASPIRE-1, ASPIRE-2 — esketamine + standard care reduced MADRS faster than placebo + standard care in MDD with acute SI; FDA approved for this indication; REMS — 2 hour post-dose observation; not standalone in ED; NEEDS_SOURCE_REVIEW for ASPIRE PMIDs |
| ketamine | 0.5 mg/kg IV over 40 min | IV | 2× weekly × 6–8 sessions then taper (off-label; specialty centers) | Wilkinson 2018 meta-analysis — single ketamine infusion reduces SI within 24 hours; off-label; specialty psychiatry centers; not ED-initiated as standalone |
Plan: Evidence-based suicide-reduction pharmacotherapy (initiated by admitting team, not in ED) (APA 2024; VA/DoD 2019)
Use these zones to know what to do based on how you feel.
Call 911 or go to the nearest emergency room right away if you have:
For discharged patients — 24–72 h outpatient appointment confirmed before leaving ED; safety plan printed and given; 988 + local crisis line numbers; means restriction agreement signed with patient + family; follow-up call from ED social work within 48–72 h (Stanley JAMA Psychiatry 2018 PMID 29387873; SAMHSA TIP 50 2015)
Guideline: APA Practice Guideline for Suicidal Behaviors 2003 + 2016 Guideline Watch + APA 2025 update + Joint Commission NPSG.15.01.01 (2019) + Stanley-Brown SPI + ED-SAFE (Boudreaux 2017) + Zero Suicide (Coffey 2015) + VA/DoD 2019