Antibiotic Builder

Empiric Antibiotic Sandbox

Pick a scenario or syndrome, set comorbidities — get a dosed, route-aware regimen with IV→PO step-down.

Quick scenarios

One tap fills every field — then tweak anything below.

Infection / syndrome

Patient factors

Allergies (click to toggle)

Comorbidity factoring

Obesity dosing notes fire automatically at BMI ≥ 30 or weight ≥ 120 kg (from the weight + height above).

Empiric regimen

2 agents
  • Ceftriaxone2 gIVq24h·5-7 days
  • Azithromycin500 mg day 1, then 250 mgIVq24h·3-5 days
    ⚠ Renal adjustment: CrCl 90 mL/min → 500 mg day 1, then 250 mg q24h.

Inpatient non-ICU CAP — beta-lactam + macrolide for typical + atypical coverage.

Targets: S. pneumoniae, H. influenzae, M. pneumoniae, C. pneumoniae, Legionella

IV → PO step-down

  • Ceftriaxone→Cefpodoxime / cefdinir / cefuroxime (culture-directed)agent-specific q12hclass switch~50% PO
    No oral ceftriaxone. Step down to an oral 3rd-gen cephalosporin or a culture-directed agent (e.g. amoxicillin, TMP-SMX, or a fluoroquinolone if susceptible).
  • Azithromycin→Azithromycin500 mg q24hdirect PO~38% PO
    Switch at the same dose; high tissue concentrations make PO equivalent for atypical coverage.

Switch when all met

  • Hemodynamically stable — off vasopressors
  • Afebrile ≥24 h (or temperature clearly trending down)
  • Clinically improving — WBC normalising, symptoms resolving
  • Tolerating oral intake; functioning GI tract (no ileus, intractable vomiting, or malabsorption)
  • No deep-seated infection mandating IV (endocarditis, meningitis, undrained abscess, S. aureus bacteraemia)

Empiric guidance only — confirm against local antibiogram, culture data, and current guidelines. De-escalate on culture results. Comorbidity flags are advisory and do not replace clinical judgement or a pharmacist review.