This handout is for gerd (chronic, empiric-to-maintenance). Your care team identified this based on: heartburn / pyrosis.
Other reasons your team may use this plan: regurgitation / acid reflux; dysphagia (alarm symptom); chronic cough / laryngeal symptoms (extra-esophageal gerd).
Take these medications exactly as prescribed. Do not stop or change a dose without talking to your provider.
| Medication | Starting dose | How | When | What it does |
|---|---|---|---|---|
| omeprazole | 20 mg PO daily 30 min before breakfast | PO | daily | ACG 2022 Katz — standard-dose PPI x 8 wk is first-line diagnostic-therapeutic maneuver |
| lansoprazole | 30 mg PO daily 30 min before breakfast | PO | daily | ACG 2022 Katz — alternative standard-dose PPI |
| esomeprazole | 20 mg PO daily 30 min before breakfast | PO | daily | ACG 2022 Katz — alternative PPI; S-isomer of omeprazole |
| pantoprazole | 40 mg PO daily 30 min before breakfast | PO | daily | ACG 2022 Katz — alternative PPI; fewer CYP2C19 interactions |
| rabeprazole | 20 mg PO daily | PO | daily | ACG 2022 Katz — alternative PPI |
| dexlansoprazole | 30 mg PO daily | PO | daily | ACG 2022 Katz — dual-release PPI; may be taken without regard to meals |
Plan: GERD empiric PPI step-up / step-down / maintenance — ACG 2022 Katz
Use these zones to know what to do based on how you feel.
Call 911 or go to the nearest emergency room right away if you have:
Symptom reassessment at 8 wk; lifestyle reinforcement (weight loss, head-of-bed elevation, avoid late meals); long-term PPI safety counseling (bone, Mg, C. diff) (ACG 2022 Katz; NICE 2024)
Guideline: ACG 2022 Clinical Guideline: Diagnosis and Management of GERD (Katz Gastroenterology 2022)